Abstract: When drilling in the Ordovician fractured-and-vuggy reservoirs in the Tahe oilfield, leakage often occurs. It is difficult to stop plugging slurry leakage, and the formula and processing of plugging slurry are complex. An idea combining ideal filling and close packing theory was put forward. Acid-soluble plugging materials were selected according to different grain sizes, and five sets of plugging slurry formula were made for fractures 1-5 mm wide. The indoor pressure capacity is 10 MPa or more, and the acid solution rate is more than 75%. Some one-bagging products were made according to the above formula, and achieved success in the Ordovician reservoirs in wells X13H and X193. The particle composition and construction technology of the one-bagging products are reasonable, and realized acid solution.