Abstract: The shelf break zone in the south of Panyu Low Uplift and on the northern slope of Baiyun Sag since the Pearl River Mouth Basin came into the post-rifting stage in the Neogene. As the primary gas-producing layer, the Zhujiang Formation was favorable for the formation of stratigraphic-lithologic traps. Stratigraphic and sedimentary facies analyses were made based on 2D and 3D seismic data and drilling information. (1) The paleo Pearl River featured a wide drainage area and abundant detrital material of terrigenous origin. (2) The land surface material of the paleo Pearl River flow domain became loose and activated due to multiple tectonic movements. (3) The paleo Pearl River delta prograded to the shelf break belt because of extensive sea level fall. Due to the influences of these three factors, the paleo Pearl River carried abundant coarse clastic debris to the southern area of Panyu Low Uplift and the northern slope of Baiyun Sag. This clastic debris formed two favorable reservoir-seal assemblages and many kinds of sedimentary bodies at the shelf break zone which had a special palaeogeomorphologic background, and thus provided favorable conditions to the development of stratigraphic-lithologic traps. The stratigraphic-lithologic traps located in the shelf edge delta of a forced regressive system tract and which formed in the slope fan and basin fan of a lowstand system tract are most advantageous for oil and gas accumulation. The stratigraphic-lithologic traps in the transgressive and highstand system tracts have poor conditions.