Abstract: The synthetic study of petroleum exploration geology is indispensable to decreasing risks in exploratory decision making and project deployment. This research which draws lessons from the theory of the hall for workshop of meta-synthetic engineering (HWME) proposed by Hsue-shen Tsien, has resolved a series of key technologies such as the real-time retrieval of multi-source and heterogeneous geology data, the knowledge management of research subjects, the data fusion of research results, and the interactive analyses of multi-touch on a big screen. An efficient work mode for cooperatively studying comprehensive geologic problems by many multi-subject experts has been set up. Furthermore, some hardware and software systems corresponding to HWME for petroleum exploration geology have been constructed and applied to some typical applications. These applications show that the research results proposed by this paper are effective, efficient and promising.