Abstract: It is generally believed that carbonate minerals can easily dissolve. This process will lead to the formation of secondary pores, thereby enlarging the reservoir space and improving the permeability of reservoir rocks. In the Qaidam Basin, clastic reservoirs of the Lower Eocene Gancaigou Formation are deposits of saline lacustrine basin, with plaster and ankerite well developed in rock flacks as revealed by polarized light microscopy and scanning electron microscope. Experimental results of fluid-rock dynamic stimulation show that the ankerite dissolution can generate secondary pores, and gypsum catalyzes the dissolution. The iron and magnesium ions generated are reactants in the transformation from koalinite to chlorite. The foliated chlorite easily blocks thin throat, leading to the decrease of permeability, while the dissolution of easily soluble minerals like ankerite increases porosity.