Abstract: Most of the traditional methods are qualitative assessments in optimized selection of the oil-gas potential exploration targets within one basin or exploration zone by applying the multidisciplinary and multi-index prospecting data and graphics. This paper, makes a case study on the Chaiwopu Sag in Xinjiang, by means of fuzzy comprehensive evaluation, utilizing multidisciplinary resources based on seismotectonics, geochemical exploration, remote sense, radioactive γ energy spectrum, soil micromagnetics, meanwhile, integrating local structure, structure position, hydrocarbon microleakage composite anomalies, oil-gas properties information and other geological essential factors, to carry out quantitative assessment on the multi-target areas, from which some of significant targets are selected as the prospecting prospects.