Abstract: Based on the latest exploration progress of the Lishu Fault Depression in the southeastern uplift of the Songliao Basin, combined with seismic, drilling and geochemical testing data, it was evaluated in this paper the organic geochemical features of hydrocarbon source rocks in the study area. The distribution characteristics and hydrocarbon generation potential of source rocks were also analyzed. By means of basin simulation and reservoir scale sequence methods, reserve amount was calculated and resource potential was predicted. The calculation results were compared with the previous evaluations, and the reasons for resource amount changes were discussed.