Abstract: Thermochemical sulfate reduction(TSR) is the major mechanism of gas reservoirs with high content of sulfureted hydrogen.The complexity of TSR mechanism demands further research which needs comprehensive simulation experiment,but different simulation experiments with different instruments lead to great diversity.In order to investigate the influence of instrument material on experimental results,a series of contrast experiments have been done.With the experiments,the followings are confirmed: ①The metal in high temperature and pressure kettle reacts with sulfur to generate metallic sulfide,so composition metal kettle is not suitable to be used as an instrument for TSR simulation experiment;②In high temperature and pressure conditions,quartz reacts with sulfate to generate silicate,so quartz tube can not be used for TSR simulation experiment;③Gold does not react with the reactant,intermediate reaction product or final reaction product,for the limited bulk volume of golden cube,the hydrocarbon product is not enough for testing light hydrocarbon,but it's enough for testing gaseous hydrocarbon components and carbon isotopes,so it is the best option to use golden cube for such kind of simulation experiment.