Abstract: The Turpan-Hami Basin locates in the northern basin group of the northern world famous Tethyan tectonic domain,which is a huge natural gas accumulation area.By comparison with petroleum geological condition of the Kuqa Depression in the Tarim Basin,it is believed that Turpan-Hami Basin possesses the geological condition of forming large-medium gas enrichment zone.According to gas distribution rules in foreland basin,it is thought that surrounding Turpan-Hami Basin,the three gas generation centers of Qiudong-Xiaocaohu,Shengbei,and Tuokexun in Turpan Depression,foreland thrust structural zone in the northern depression,slope br eak zone of foreland depression,and southern foreland uplift zone are favorable exploration direction for large-medium natural gas enrichment zone.It points out in this paper that lacustrine mudstone of Upper Permian and marine source rock of Carboniferous developed in the lower assemblage of Turpan-Hami Basin,are the possible large natural gas reservoir areas.It also preliminarily predicts that Turpan-Hami Basin is with rich CBM resources,and great exploration potential.