Abstract: Controlled by multivariate dynamics such as the EW-oriented Tethys tectonic zone and the NNE-oriented West Pacific Ocean border tectonic zone,the Hefei Basin has the following characteristics:multi-period of basin formation,frequent tectonic movement,small scale of sedimentation and extension,and involving superficial tectonic layers only.These features are unfavorable to the formation of Mesozoic and Cenozoic hydrocarbon source rocks and the inversion of organic matter in Hefei Basin.However,the (Paleozoic) should be the focal point for the future exploration.